Confuse or stupefy (someone), especially with alcohol.
(archaic) Go on a drinking bout.
Late 16th century (in the sense ‘go on a drinking bout’): of unknown origin.
“You have no chance of any sense, he’s let the drink fuddle him.”
Aginer (noun) (US informal)
A person who is against something; one who opposes a proposal, course of action, point of view, etc. Also more generally: a person having a habitually negative attitude; one who opposes any change as a matter of principle.
Early 20th century; earliest use found in Westminster (Philadelphia). From agin, regional and colloquial variant of again + -er.